Arizona Cardinals vs Indianapolis Colts Betting Pick & Prediction for 10/12

NFL Game preview

The Arizona Cardinals are set to play the Indianapolis Colts in Week 6 of the 2025 NFL season. The game will take place at Lucas Oil Stadium in Indianapolis. The stadium has a retractable roof, so weather conditions will not affect the game much.

Arizona enters the game with a 2-3 record, while the Colts have a 4-1 record. The Cardinals have been average on the road, with a 1-1 record away from home. Meanwhile, the Colts have been strong at home with a 3-0 record. The game will be broadcast on FOX, and kickoff is scheduled for 1:00 PM on Sunday, October 12, 2025.

Arizona Cardinals Team Preview

The Arizona Cardinals have faced some tough games recently. They lost to the Tennessee Titans 22-21 in a close game. In that game, the Cardinals had 192 passing yards and 168 rushing yards. Their defense forced one interception.

The Cardinals had a hard time against the Seattle Seahawks, losing 23-20. Kyler Murray threw for 200 yards with two touchdowns and two interceptions. The team’s rushing game only managed 89 yards.

In their game against the San Francisco 49ers, the Cardinals lost 16-15. Murray had 159 passing yards and one touchdown. The rushing game contributed 106 yards, but it wasn’t enough to secure a win.

Cardinals vs Colts Game Day Info

  • Sport: NFL
  • Teams: Arizona Cardinals vs. Indianapolis Colts
  • Venue: Lucas Oil Stadium in Indianapolis, IN USA
  • Date: Sunday, October 12, 2025
  • Betting Odds: Cardinals Moneyline +250, Colts Moneyline -311, Cardinals Spread +6.5 (-109), Colts Spread -6.5 (-112), Total Over 47.5 (-108), Total Under 47.5 (-112)

Indianapolis Colts Team Preview

The Indianapolis Colts are coming off a big win over the Las Vegas Raiders. They scored 40 points while holding the Raiders to only 6. Daniel Jones led the offense with 212 passing yards and 2 touchdowns, and Jonathan Taylor added 66 rushing yards with 3 touchdowns.

Earlier in the season, the Colts faced a tough game against the Los Angeles Rams. They lost 27-20, despite Daniel Jones passing for 262 yards. The defense struggled, allowing 360 passing yards from the Rams.

Jonathan Taylor has been a key player this season. He leads the team with 480 rushing yards and 6 touchdowns over five games. The Colts’ defense will look to improve, especially with several players on the injury list, including Kenny Moore II and Grover Stewart.

BTB Betting Pick

The Indianapolis Colts are favored by 6.5 points against the Arizona Cardinals. The Colts scored 377 points last season, while the Cardinals scored 400. With the Cardinals having a stronger offense, taking the Cardinals to cover the spread at +6.5 seems reasonable.

The total for the game is set at 47.5 points. The Cardinals allowed 379 points last season, and the Colts allowed 427. Both defenses rank lower in points allowed, suggesting a higher scoring game. Therefore, taking the over 47.5 is a solid choice.