Louisville Cardinals vs Memphis Tigers Prediction & Odds – November 15, 2026

Louisville brings an unbeaten start to FedExForum for a meeting with Memphis, which has already experienced both a narrow win and a lopsided loss. The Cardinals’ first road assignment presents a different test.

Game details and odds

Sunday, November 15, 2026 at 1:00 pm EST · FedExForum

Total: 163.5 — over -110, under -110.

Odds checked November 15, 2026 00:02 UTC. Odds subject to change.

Louisville’s scoring meets its first road test

Louisville is averaging 95.5 points and 50.5 rebounds through two games, with Karter Knox leading the team at 8.5 rebounds per game. The Cardinals have shot 49% from the field, but their 30% three-point mark suggests their early scoring has not depended on consistently accurate outside shooting.

Both Louisville wins came on its home floor, though the margins varied considerably. The Cardinals beat Chattanooga 84-70 in their opener, then defeated Morehead State 107-57. That second result showed how far Louisville can pull away when its scoring takes off, while the Chattanooga game offered a narrower winning margin. Neither result tells us how the Cardinals will respond away from their own arena. What the two games do establish is a team that has reached 84 points in each outing while holding both opponents to 70 or fewer.

Memphis looks to answer a defensive setback

Memphis is averaging 83.3 points through three games, and Jayden Reid leads the Tigers with 23.0 points and 3.3 assists per game. Their 38% shooting from three gives them a potential counter to Louisville’s scoring, but allowing 89.7 points per game makes defensive resistance a central question.

The Tigers’ results show both their resilience and the cost of a difficult defensive night. They beat Iowa State 80-76 at a neutral site, then edged VCU 89-88 at FedExForum. Memphis followed those wins with a 105-81 road loss to Vanderbilt. Scoring at least 80 points in all three games has kept the offense productive, but the points conceded have climbed in each successive outing. The VCU result also shows Memphis can win a close game at this venue, even when its opponent scores heavily.

Injury news

Louisville Cardinals: No player statuses returned in the latest check..

Memphis Tigers: No player statuses returned in the latest check..

Availability checked November 15, 2026 00:02 UTC. Reported statuses may change; final lineups are not confirmed here.

BTB Betting Pick

Winner pick: Louisville Cardinals.

Louisville’s early scoring and rebounding give it the edge, especially with Memphis coming off a high-scoring loss. The pick carries uncertainty: the Cardinals have yet to play a road game.

Original winner pick recorded November 15, 2026 00:02 UTC. Subsequent updates retain that selection.