Athletics vs San Diego Padres Betting Pick & Prediction for Game on 5/22

MLB game preview

The Athletics will travel to PETCO Park to play the San Diego Padres in an MLB regular season game. The game is scheduled for Friday, May 22, 2026, at 9:40 PM. Fans can catch the action on NBC.

The Athletics are currently first in the AL West with a record of 25-24. They have won their last two games. The Padres hold a 29-20 record and are second in the NL West. However, they have lost their last two games. The weather forecast indicates mild conditions with a light breeze.

Athletics Team Preview

The Athletics have had mixed results in their recent games. They managed to win two out of three games against the Los Angeles Angels. In their last game against the Angels, they won 6-5 with Jeff McNeil and Nick Kurtz contributing with key hits.

The Athletics’ hitting lineup has some strong performers. Shea Langeliers leads the team with a .322 batting average and 12 home runs. Nick Kurtz has also been effective with a .277 average and 8 home runs.

On the pitching side, Jeffrey Springs is the probable starter for the next game. Springs has a 3-4 record with a 3.93 ERA this season. The Athletics will need a solid performance from him against the Padres.

Athletics vs Padres Game Day Info

  • Sport: MLB
  • Teams: None Athletics vs San Diego Padres
  • Venue: PETCO Park in San Diego, CA
  • Date: Friday, May 22, 2026
  • Betting Odds: Athletics Moneyline +112, Padres Moneyline -134, Athletics Runline +1.5 (-190), Padres Runline -1.5 (+157), Total Over 8.0 (-110), Total Under 8.0 (-110)

San Diego Padres Team Preview

The San Diego Padres have had a mixed performance recently. They won against the Mariners on May 17th with an 8-3 score. Lucas Giolito pitched five innings, giving up only one hit but allowing three earned runs.

In their recent series against the Dodgers, the Padres struggled. They lost two out of three games, with scores of 5-4 and 4-0. Michael King pitched well in their lone win, throwing seven scoreless innings with nine strikeouts.

The Padres’ batting lineup has room for improvement. Their batting average ranks 22nd in the league at .221. However, their power hitting shows promise, as they have hit 49 home runs this season, which ranks 16th.

BTB Betting Pick

The Padres are favored with a moneyline of -134. They have a better pitching record with an ERA of 3.93, ranked 12th, compared to the Athletics’ ERA of 4.38, ranked 22nd. Considering the Padres’ stronger pitching and the Athletics’ lower batting average, the pick is for the Padres to win.

The total is set at 8.0 with both the over and under at -110. The Padres have given up fewer home runs, which suggests a lower scoring game. Given the Athletics’ batting struggles, the projected score is 4-3 in favor of the Padres. Therefore, the recommendation is to take the under.