Jacksonville Jaguars vs Denver Broncos Betting Pick & Prediction for 12/21

This article was published on Dec 17, 2025. Today’s picks NFL picks

NFL Game preview
The Jacksonville Jaguars will visit the Denver Broncos in Week 16 of the 2025 NFL season. The game is scheduled for Sunday, December 21, at 4:05 PM at Empower Field at Mile High. Fans can catch the action on FOX. The Jaguars come into this game with a record of 10-4. They have been strong both at home and on the road this season. The Broncos, with a record of 12-2, have been unbeaten at home. Weather forecasts predict a very cold day with broken clouds.

Jacksonville Jaguars Team Preview

The Jacksonville Jaguars have been on a roll, winning their last four games. In their most recent game against the New York Jets, the Jaguars won 48-20. Trevor Lawrence shined with 330 passing yards and five touchdowns, leading the team to a convincing victory.

Travis Etienne Jr. has been a key player for the Jaguars this season. He has 949 rushing yards and seven touchdowns over 14 games. However, the team will miss Bhayshul Tuten, who is out with a finger injury.

Defensively, the Jaguars have been strong, with players like Montaric Brown and Antonio Johnson making significant contributions. The team has had issues with injuries, including Cooper Hodges and Travis Hunter. Despite these challenges, the Jaguars continue to perform well, aiming to extend their winning streak.

Jaguars vs Broncos Game Day Info

  • Sport: NFL
  • Teams: Jacksonville Jaguars vs. Denver Broncos
  • Venue: Empower Field at Mile High, Denver, CO
  • Date: Sunday, December 21, 2025
  • Betting Odds: Jaguars +141, Broncos -168

Denver Broncos Team Preview

The Denver Broncos are coming off a series of wins, with the latest being a 34-26 win over the Green Bay Packers. Bo Nix led the offense with 302 passing yards and four touchdowns. Courtland Sutton and Troy Franklin were key receivers, combining for two touchdowns and 198 yards.

In an earlier game, the Broncos beat the Las Vegas Raiders 24-17. RJ Harvey shone with 75 rushing yards and a touchdown. Bo Nix added 204 passing yards, keeping the Broncos’ offense moving efficiently.

Injuries are affecting the Broncos’ roster with key players like J.K. Dobbins and Matt Henningsen out for the season. The team will rely on their depth to maintain their winning form. Ben Powers is questionable but might return soon, which would be a boost to the offensive line.

BTB Betting Pick

The Broncos are favored by 3 points against the Jaguars. With Denver’s strong defense, ranked 3rd in opponent scoring, they are likely to cover the spread. The projected score is Broncos 24, Jaguars 20, which supports taking Denver -3.

The total for the game is set at 45.5 points. The Jaguars have struggled offensively, ranking 24th in scoring. Denver’s defense is one of the best, so a low-scoring game is expected. The projected total score is 44, making the under 45.5 the recommended pick.