Atlanta Falcons vs Arizona Cardinals Betting Pick & Prediction for 12/21

In Week 16 of the 2025 NFL season, the Atlanta Falcons travel to Glendale to play the Arizona Cardinals. The game will take place at State Farm Stadium, with a retractable roof ensuring a controlled environment. Scheduled for Sunday, December 21, at 4:05 PM, fans can catch the action live on FOX.

The Falcons, with a 5-9 record, aim to improve their road performance, currently standing at 3-5. On the other hand, the Cardinals sit at 3-11, hoping to secure a second home win. The Falcons enter as slight favorites with a spread of -2.5, while the over/under is set at 48 points.

Atlanta Falcons Team Preview

The Atlanta Falcons have had mixed results in recent games. They had a close win against the Tampa Bay Buccaneers with a score of 29-28. Kirk Cousins was impressive, throwing for 373 yards and three touchdowns. Kyle Pitts Sr. also played well, scoring three touchdowns with 166 receiving yards.

In another recent game, the Falcons struggled against the Seattle Seahawks, losing 37-9. They had only 154 passing yards and two interceptions. Bijan Robinson was a bright spot, rushing for 86 yards in the game.

The Falcons have several injuries that could affect their performance. Notably, Michael Penix Jr. and Drake London are on the injured list. With these key players out, the team will need others to step up to maintain their performance.

Falcons vs Cardinals Game Day Info

• Sport: NFL
• Teams: Atlanta Falcons vs. Arizona Cardinals
• Venue: State Farm Stadium in Glendale, AZ
• Date: Sunday, December 21, 2025
• Betting Odds: Falcons Moneyline -147, Cardinals Moneyline +124

Arizona Cardinals Team Preview

The Arizona Cardinals have faced tough competition this season. In recent games, they lost to the Houston Texans 40-20 and the Los Angeles Rams 45-17. Their defense has struggled, allowing high scores in these games.

On offense, the Cardinals rely on Jacoby Brissett, who has thrown for 2,708 yards and 18 touchdowns in 11 games. Trey McBride is a key target, with 105 receptions and 1,071 yards. Injuries have impacted the team, with key players like Kyler Murray and Zay Jones out for the season.

The Cardinals’ defense ranks 14th in opponent scoring, allowing 379 points last season. Budda Baker and Jalen Thompson are important players in the secondary. The team will look to improve its rushing defense after allowing 143 yards to the Texans and 249 yards to the Rams.

BTB Betting Pick

The Falcons are favored by 2.5 points against the Cardinals. The Falcons have a strong passing game, ranking 5th in the league, which should help them cover the spread. With a projected score of Falcons 27, Cardinals 24, taking the Falcons to cover seems reasonable.

The total for the game is set at 48.0. Both teams have offenses that can score, ranking 13th and 12th respectively. Given this, and the projected total score of 51, the over looks like a solid pick.