Kansas City Chiefs vs Tennessee Titans Betting Pick & Prediction for 12/21

The Kansas City Chiefs travel to Nashville to take on the Tennessee Titans in Week 16 of the 2025 NFL season. The game is set for Sunday, December 21, at 1:00 PM at Nissan Stadium. Fans can tune in on CBS to catch the action on a cool and overcast afternoon.

The Chiefs, led by head coach Andy Reid, come into this game with a 6-8 record. They have struggled on the road, with a 1-5 record away from Arrowhead Stadium. The Titans, with interim head coach Mike McCoy, are looking for their first home win of the season, currently sitting at 0-7 in Nashville. Both teams aim to improve their standing in their respective divisions.

Kansas City Chiefs Team Preview

The Kansas City Chiefs have had a tough stretch in their recent games. They lost 16-13 to the Los Angeles Chargers at home. In that game, Patrick Mahomes threw for 190 yards but had two interceptions, and the team managed only 49 rushing yards.

In their previous game against the Houston Texans, the Chiefs lost 20-10. Mahomes struggled again with three interceptions and only 148 passing yards. Kareem Hunt was a bright spot, rushing for 30 yards and a touchdown.

The Chiefs will be without their star quarterback, Patrick Mahomes, due to a torn ACL. Gardner Minshew will step in as the starting quarterback. The team will need to rely on players like Travis Kelce and Kareem Hunt to step up in Mahomes’ absence.

Chiefs vs Titans Game Day Info

• Sport: NFL
• Teams: Kansas City Chiefs vs. Tennessee Titans
• Venue: Nissan Stadium in Nashville, TN USA
• Date: Sunday, December 21, 2025
• Betting Odds: Chiefs Moneyline -187, Titans Moneyline +155

Tennessee Titans Team Preview

The Tennessee Titans have had a challenging season. They lost 37-24 to the San Francisco 49ers in their last game. Despite the loss, Tony Pollard stood out with 104 rushing yards and a touchdown.

In Week 14, the Titans secured a win against the Cleveland Browns with a score of 31-29. Tony Pollard played a key role, rushing for 161 yards and two touchdowns. Cameron Ward contributed with two touchdown passes.

The Titans face several injury issues. Calvin Ridley and Xavier Woods are out for the season. Van Jefferson is questionable with a back injury for the upcoming game.

BTB Betting Pick

The Kansas City Chiefs are favored by 3.5 points against the Tennessee Titans. The Chiefs have a strong defense, ranked 4th in opponent scoring. Meanwhile, the Titans rank 27th in that category. We recommend picking the Chiefs to cover the spread. Our projected score is Chiefs 24, Titans 17.

The total for this game is set at 37.5 points. Both teams have defenses that can limit scoring, with the Chiefs having a particularly strong showing. The Titans’ offense ranks 25th in scoring, which might struggle against the Chiefs’ defense. We recommend taking the under. Our projected total is 41 points.