Carolina Panthers vs San Francisco 49ers Betting Pick & Prediction for 11/24

The Carolina Panthers will travel to Levi’s Stadium to take on the San Francisco 49ers in Week 12 of the 2025 NFL season. The game is set for Monday night, November 24, with kickoff at 8:15 PM. Fans can catch all the action on ESPN.

The Panthers have a record of 6-5 this season, with a road record of 3-3. They are led by head coach Dave Canales. On the other side, the 49ers hold a 7-4 record and are 2-2 at home. Kyle Shanahan is the head coach for the 49ers. Both teams will look to improve their standings in their respective divisions.

Carolina Panthers Team Preview

The Carolina Panthers have had mixed results in their recent games. They have secured wins against the Green Bay Packers and New York Jets, with scores of 16-13 and 13-6, respectively. However, they have faced defeats against the New Orleans Saints, losing 17-7, and the Buffalo Bills, losing 40-9.

Rico Dowdle has been a key player for the Panthers, excelling in the run game. Against the Cowboys, Dowdle ran for 183 yards, and he also had a strong performance with 130 rushing yards against the Packers. Bryce Young has also contributed, though he had a challenging game against the Saints with only 124 passing yards and one interception.

The Panthers have a few players dealing with injuries. David Moore, Robert Hunt, Brady Christensen, and Patrick Jones II are all out for extended periods. Trevin Wallace, Xavier Legette, and Lathan Ransom are listed as questionable for their next game.

Panthers vs 49ers Game Day Info

• Sport: NFL
• Teams: Carolina Panthers vs. San Francisco 49ers
• Venue: Levi’s Stadium in Santa Clara, CA
• Date: Monday, November 24, 2025
• Betting Odds: Panthers +270, 49ers -339

San Francisco 49ers Team Preview

The San Francisco 49ers have had an up-and-down season so far. They have shown they can put up big scores, like in their 41-22 win over the Arizona Cardinals. However, they have also faced tough losses, such as their 42-26 defeat by the Los Angeles Rams.

Christian McCaffrey is a key player for the 49ers. He has been reliable in both rushing and receiving. His best performance came against the Falcons, where he rushed for 129 yards and scored two touchdowns.

Injuries have affected the 49ers’ lineup. Key players like Nick Bosa and Fred Warner are out for the season. This puts more pressure on other players to step up and fill those gaps.

BTB Betting Pick

The Carolina Panthers are set as +7.0 underdogs against the San Francisco 49ers. The Panthers’ offense ranks low in several areas, while the 49ers have a solid attack. The 49ers are likely to win by more than a touchdown, so taking the 49ers to cover the -7.0 spread is a reasonable choice. Projected score: 49ers 31, Panthers 20.

The over/under for the game is set at 48.5. The Panthers have a weak defense, giving up 534 points last season, while the 49ers have a strong offense. This suggests a high-scoring game, making the over 48.5 a good pick. The projected total score for the game is 51 points.