Tampa Bay Buccaneers vs Buffalo Bills Betting Pick & Prediction for 11/16

The Tampa Bay Buccaneers will visit the Buffalo Bills in Week 11 of the 2025 NFL season. This game will be held at Highmark Stadium in Orchard Park, NY, on Sunday, November 16, at 1:00 PM. The weather is expected to be very cold and breezy with broken clouds, which might affect play on the outdoor field.

Both teams enter this game with a 6-3 record, making this a critical matchup. The Buccaneers have excelled on the road with a 4-1 record, while the Bills have been strong at home, also with a 4-1 record. Fans can catch the game on CBS to see how these teams perform under the chilly conditions. The odds favor the Bills with a -254 moneyline, while the Buccaneers are listed at +209.

Tampa Bay Buccaneers Team Preview

The Tampa Bay Buccaneers have shown a mix of results in recent games. They lost to the New England Patriots with a score of 28-23. In that game, Baker Mayfield threw for 273 yards and three touchdowns.

The Buccaneers had a big win over the New Orleans Saints, ending the game 23-3. They had 88 rushing yards and forced two interceptions. Sean Tucker led the team with 42 rushing yards and a touchdown.

Injuries are affecting the Buccaneers’ lineup. Key players like Mike Evans and Chris Godwin are dealing with issues. Other players, such as Haason Reddick, are also questionable for upcoming games.

Buccaneers vs Bills Game Day Info

• Sport: NFL
• Teams: Tampa Bay Buccaneers vs. Buffalo Bills
• Venue: Highmark Stadium in Orchard Park, NY USA
• Date: Sunday, November 16, 2025
• Betting Odds: Buccaneers +209, Bills -254

Buffalo Bills Team Preview

The Buffalo Bills are coming off a tough loss to the Miami Dolphins with a score of 30-13. Despite the loss, Josh Allen had a solid performance with 306 passing yards and 2 touchdowns. James Cook added 87 rushing yards to the team’s total, but it wasn’t enough to overcome Miami’s strong run game.

Earlier in the season, the Bills had a strong win against the Kansas City Chiefs, finishing 28-21. In that game, Josh Allen threw for 273 yards and a touchdown. James Cook also impressed with 114 rushing yards, helping the team control the game on the ground.

The Bills have shown they can perform well, as seen in their 40-9 win over the Carolina Panthers. James Cook led the charge with an impressive 216 rushing yards and 2 touchdowns. The defense also played well, forcing 3 fumbles and holding the Panthers to just 9 points.

BTB Betting Pick

The Buffalo Bills are favored by 5.5 points against the Tampa Bay Buccaneers. The Bills’ offense is strong, scoring 525 points last season, ranking 2nd in the league. Given the Buccaneers’ defensive rank of 15th in opponent scoring, the Bills are likely to cover the spread. A projected score of Bills 28, Buccaneers 20 supports taking the Bills -5.5.

The total for the game is set at 48.0 points. Both teams have shown the ability to score, but their defenses are not far behind in performance. The Buccaneers’ defense ranks 18th in opponent offensive yards, while the Bills’ defense ranks 17th. A projected total of 48 points suggests taking the under 48.0 is a safe bet.