Kansas City Chiefs vs Buffalo Bills Betting Pick & Prediction for 11/2

In Week 9 of the 2025 NFL season, the Kansas City Chiefs take on the Buffalo Bills at Highmark Stadium. The game is set for Sunday, November 2, at 4:25 PM and will be broadcast on CBS. The weather forecast for the day is cool with scattered clouds.

The Chiefs come into the game with a 5-3 record, struggling a bit on the road with a 1-2 record. They are led by head coach Andy Reid. The Bills have a 5-2 record and have been strong at home, holding a 3-1 record. Their head coach is Sean McDermott. This AFC matchup will be one to watch as both teams aim to strengthen their standings.

Kansas City Chiefs Team Preview

The Kansas City Chiefs have been strong this season. In their last game, they won against the Washington Commanders 28-7. Patrick Mahomes led the offense with 299 passing yards and three touchdowns.

In the last five games, the Chiefs have shown they can score. They won against the Las Vegas Raiders 31-0 and the Detroit Lions 30-17. Their offense has been led by Mahomes, who has passed for over 2000 yards this season.

The Chiefs have some key players injured. Deon Bush and Janarius Robinson are out for the season. Isiah Pacheco is questionable for the next game with a knee injury.

Chiefs vs Bills Game Day Info

• Sport: NFL
• Teams: Kansas City Chiefs vs. Buffalo Bills
• Venue: Highmark Stadium in Orchard Park, NY USA
• Date: Sunday, November 2, 2025
• Betting Odds: Chiefs Moneyline -131, Bills Moneyline +110, Chiefs Spread -2.0 (-110), Bills Spread +2.0 (-111), Total Over 52.5 (-108), Total Under 52.5 (-111)

Buffalo Bills Team Preview

The Buffalo Bills have had an up-and-down season so far. In their recent game against the Carolina Panthers, they won 40-9. Josh Allen led with 163 passing yards and a touchdown, while James Cook rushed for 216 yards and two touchdowns.

The Bills struggled in their game against the Atlanta Falcons, losing 24-14. Josh Allen threw for 180 yards, two touchdowns, but also had two interceptions. James Cook contributed 87 rushing yards, but it wasn’t enough to secure a win.

Buffalo’s defense has shown strength, ranking high in sacks and interceptions. Key players like A.J. Epenesa and Greg Rousseau have made an impact with sacks. However, injuries could pose a challenge, with key players like Ed Oliver and Taylor Rapp on the injured reserve list.

BTB Betting Pick

The Kansas City Chiefs are favored by 2 points against the Buffalo Bills. Given the Chiefs’ strong defense, ranked 4th in opponent scoring, they are likely to cover the spread. The projected score is Chiefs 27, Bills 24, suggesting a close game but favoring the Chiefs to win by more than 2 points.

The total for this game is set at 52.5 points. With both teams having strong offenses, especially the Bills ranked 2nd in scoring, the game is likely to go over the total. The projected combined score is 51, but both teams have the potential to score more, making the over a viable pick.