Cleveland Cavaliers vs New York Knicks Betting Pick & Prediction for 10/22

The NBA Regular Season kicks off with the Cleveland Cavaliers visiting the New York Knicks at Madison Square Garden. Both teams are starting their campaigns with fresh slates, aiming for a strong start. This game will be broadcasted on ESPN on Wednesday, October 22, 2025, at 7:00 PM.

Cleveland, led by head coach Kenny Atkinson, is part of the Eastern Conference’s Central Division. They finished the preseason with a 1-3 record. Meanwhile, the Knicks, under head coach Mike Brown, are from the Atlantic Division in the Eastern Conference. They had a successful preseason with a 4-1 record. Fans are eager to see how these teams perform as the season begins.

Cavaliers vs Knicks Game Day Info

• Sport: NBA
• Teams: Cleveland Cavaliers vs. New York Knicks
• Venue: Madison Square Garden
• Date: Wednesday, October 22, 2025
• Betting Odds: Cavaliers Spread -1.5 (-108), Knicks Spread +1.5 (-112), Cavaliers MoneyLine -117, Knicks MoneyLine -102, Over/Under 226.5

Cleveland Cavaliers Team Preview

The Cleveland Cavaliers recently played well against the Detroit Pistons. They won the game by 18 points, finishing with a score of 118-100. Key players like Jarrett Allen contributed 15 points and six rebounds, helping the team secure the win.

In a previous game against the Boston Celtics, the Cavaliers faced challenges. They lost by 31 points with a score of 107-138. Jaylon Tyson led the team with 16 points, but it was not enough to overcome the Celtics.

The Cavaliers also had a close game against the Chicago Bulls. They lost by seven points with a score of 112-119. Donovan Mitchell stood out with 22 points and six rebounds, showing his strength on the court.

New York Knicks Team Preview

The New York Knicks recently played a game against the Charlotte Hornets and won 113-108. Jalen Brunson led the team with 31 points, 7 rebounds, and 6 assists. Mikal Bridges added 16 points and 7 rebounds in the victory.

In their previous game, the Knicks faced the Washington Wizards and lost 120-103. Tyler Kolek was a bright spot with 20 points and 6 assists. Despite the loss, the Knicks showed determination on the court.

The Knicks also secured a win against the Minnesota Timberwolves with a score of 100-95. Mikal Bridges contributed 15 points and 4 rebounds in this game. Karl-Anthony Towns grabbed 11 rebounds, helping the Knicks hold off the Timberwolves.

BTB Betting Pick

The Cleveland Cavaliers are favored by 1.5 points with odds of -108. Given the odds and the lack of detailed stats, betting on the Cavaliers to cover the spread seems reasonable. With the Cavaliers as the favorite, they might have a slight edge over the Knicks.

The total for the game is set at 226.5 points. With no specific data on scoring or defense, betting on the under at -110 might be a safer choice. The lack of detailed scoring stats suggests a cautious approach to the total points.