Indiana Pacers vs New York Knicks Betting Pick & Prediction 5/21/25

The Pacers (+157) head to Madison Square Garden to take on the Knicks (-186) at 8:00 ET. New York is favored by 4.5 and the over/under is 223.5. TNT will broadcast this Eastern Conference matchup.

Indiana (50-32) is currently on a two-game win streak and sits fourth in the East. New York (51-31) is third in the conference and second in the Atlantic Division.

INDIANA PACERS VS NEW YORK KNICKS BETTING PICK

The Pick: Indiana Pacers +4.5

This game will be played at Madison Square Garden at 8:00 ET on Wednesday, May 21st.

WHY BET THE INDIANA PACERS:

• We have this one finishing with a projected score of 130-129 in favor of the Pacers.
• Our projections have Pascal Siakam finishing with 20 points, 7 rebounds and 3 assists.
• From the field, we have the Pacers finishing with a field goal percentage of 49.0% and knocking down 15 threes.

Can Indiana Pull Out the Win as Road Underdogs?

With a 114-105 win over the Cavaliers on Tuesday, the Pacers improved to 50-32 for the season. Indiana, who were +8.5 point underdogs, not only won but covered the spread. The game’s total points of 219 fell short of the 229 O/U line.

Indiana turned the game around after trailing 31-19 in the 1st quarter. They went on a pivotal 10-0 run, extending the score from 64-62 to 74-62, and outscored Cleveland 33-20 in the 3rd quarter. The teams finished the 4th quarter tied at 29 points each.

Tyrese Haliburton’s 31 points, 8 assists, and 6 threes at a 60% clip from deep led the Pacers to a win over the Cavaliers. He shot 66.7% from the field, with 15 of his points coming in the 2nd quarter. Andrew Nembhard added 18 points, scoring 9 in the 4th quarter, while Pascal Siakam contributed 21 points despite shooting 40%.

As a team, the Pacers hit 15 threes, shooting 42.9% from beyond the arc and 50% overall. Haliburton’s 6 threes were key, and Nembhard connected on 3, shooting 50% from deep.

The Pacers gave up 31 points in the 1st quarter but tightened up defensively in the 2nd and 3rd, allowing just 25 and 20 points, respectively. They gave up 29 points in the 4th but still managed to hold the Cavaliers to 105 points overall.

Indiana’s defense held Cleveland to 38% shooting from the field, including just 9 made threes on 25% shooting. The Pacers also recorded 8 steals and 8 blocks in the game.

Can New York Lock in a Home Win?

With a dominant 119-81 win over the Celtics on Friday, the Knicks improved to 51-31 for the season. Playing at home, New York entered the game as -3 point favorites and covered the spread with ease. The total points for the game came in at 200, falling short of the 211.5-point line.

New York took control early, outscoring Boston 38-17 in the 2nd quarter. An 11-0 run extended their lead from 71-43 to 82-43, and they led 92-57 going into the 4th quarter.

In their 119-81 win over the Celtics, the Knicks hit 16 threes at a 35.6% clip, with an overall shooting percentage of 46.2%. OG Anunoby and Jalen Brunson each scored 23 points, with Anunoby adding 9 rebounds despite shooting 38.9% from the field and 30.8% from deep.

Mikal Bridges contributed 22 points, hitting 4 threes at 66.7%, while Karl-Anthony Towns added 21 points, including 11 in the opening quarter. Bridges also scored 10 points in the 1st quarter and added 8 more in the 4th.

The Knicks put on a defensive clinic against the Celtics, holding them to just 81 points on Friday. New York gave up 20 points in both the 1st and 3rd quarters, while their best defensive effort came in the 2nd, where they allowed only 17 points. The 4th quarter saw the Celtics score 24 points, but it wasn’t enough to threaten the Knicks’ big win.

Overall, the Knicks limited Boston to 36% shooting from the field, including 30% from beyond the arc, where the Celtics made 12 threes. New York also sent Boston to the free-throw line just 10 times, where they converted 7. The Knicks grabbed 40 defensive rebounds, allowing 9 offensive boards, and added 7 steals and 6 blocks.